AOD-9604: The Lipolytic Peptide Derived from Growth Hormone

AOD-9604 is a synthetic peptide derived from the C-terminal fragment of human growth hormone — designed to isolate its fat-burning properties while eliminating the metabolic side effects associated with direct GH administration.

By UAE Peptide Clinic Research Desk

AOD-9604 is a synthetic 16-amino-acid peptide derived from the C-terminal fragment of human growth hormone (residues 177-191). Its development was motivated by a specific goal: isolate the fat-burning properties of hGH while eliminating the metabolic side effects — particularly the hyperglycaemia and insulin resistance associated with direct GH administration. The result is a compound that stimulates lipolysis without measurably affecting IGF-1 or insulin sensitivity.

Mechanism of Action

AOD-9604 stimulates lipolysis — the breakdown of stored fat, particularly triglycerides in adipocytes — through a mechanism involving beta-3 adrenergic receptor activation and cyclic AMP elevation. These pathways are distinct from the classical GH receptor pathway, which is what allows AOD-9604 to influence fat metabolism without the side effects of full-length GH. Preclinical data consistently shows selective adipose tissue reduction.

Clinical Applications

AOD-9604 is most commonly used in protocols targeting visceral and subcutaneous fat reduction, particularly as an adjunct to caloric management and exercise. It is not a replacement for lifestyle modification, but functions as an accelerant to fat metabolism when used alongside a structured programme. Preliminary research has also shown signal in osteoarthritis and cartilage repair models.

AOD-9604 is available as part of lean body composition protocols at UAE Peptide Clinic. Our physicians will assess your metabolic profile and goals before recommending. Explore it at /peptides/aod-9604 or book a consultation at /book.