MOTS-C Protocol
The Metabolic Optimizer
A mitochondrial-derived peptide studied for its potential role in AMPK pathway activation, glucose metabolism, and insulin sensitivity. Researched in the context of exercise capacity and metabolic health.
MOTS-C has been studied in relation to metabolism, energy, and vitality. Some research suggests it may support mitochondrial function, metabolic efficiency, and exercise recovery. Results depend on individual patient profile and are assessed by your prescribing physician.
- Typical dose: 5–10 mg/week
- Frequency: 3–5x per week
- Cycle: 8–12 weeks on, 4 weeks off
- Purity: 99.0%
- Storage: Freeze unmixed (-18°C). Refrigerate reconstituted (2–8°C), use within 30 days.
What is MOTS-C?
MOTS-C is a microprotein encoded within the mitochondrial genome, making it one of the very few peptides that originates from mitochondrial DNA rather than nuclear DNA. Discovered in 2015 by researchers at USC, it has since attracted significant scientific interest for its potential role in metabolic regulation, insulin sensitivity, and exercise-related cellular signalling. In the UAE, MOTS-C is available as a physician-supervised protocol through UAE Peptide Clinic.
How MOTS-C is studied
Preclinical research has examined MOTS-C for its potential to activate the AMPK pathway, a key metabolic regulator that responds to cellular energy status. Studies in mouse models have explored associations between MOTS-C and improved insulin sensitivity, reduced fat accumulation, and enhanced exercise capacity. Human studies remain in early stages, and clinical outcomes should not be assumed from animal research. Your prescribing physician will review the evidence base during your consultation.
MOTS-C and metabolic health in Dubai
Dubai's active population, from high-performance athletes to busy professionals focused on body composition and energy, has shown increasing interest in mitochondrial peptides. MOTS-C stands out because of research linking it to glucose metabolism and exercise performance. Some patients combine MOTS-C with NAD+ to support what is often described as a mitochondrial health stack, though any combination requires physician review and approval.
MOTS-C protocols in the UAE
MOTS-C is prescribed by DHA-registered physicians following a clinical consultation at UAE Peptide Clinic. Standard protocols typically involve subcutaneous injections 3 to 5 times per week at doses of 5 to 10mg, as directed by your physician. The protocol runs for 8 to 12 weeks with a 4-week break between cycles. MOTS-C vials are pharmaceutical grade and cold-chain delivered across Dubai, Abu Dhabi, and all UAE emirates.
- Prescription required — DHA physician consultation included
- Typical dose: 5 to 10mg, 3 to 5 times per week
- Cycle: 8 to 12 weeks on, 4 weeks off
- Often combined with NAD+ in a mitochondrial health stack
- Cold-chain delivery to all UAE emirates